Internal Medicine/Cardiology


John A. Ambrose, MD, FACC
Professor of Medicine, UCSF
Chief of Cardiology, UCSF
Program Director, Cardiology Fellowship

Medical School:

New York Medical College, New York


Mount Sinai Hospital, New York


Mount Sinai Hospital, New York

Board Certified:

National Board of Medical Examiners
American Board of Internal Medicine
American Board of Internal Medicine, Cardiology

Awards and Recognition:

  1. Best Doctors in America

  2. Simon Dack Award for Best Teacher in Cardiology              

  3. New York Medical College Alumni Assoc. Gold Medal of Honor

  4. NRCC National Leadership Award

  5. Physician’s Advisory Board (NRCC) Honorary Co-Chairman

  6. St. Vincent’s Hospital Honored Teacher Award 



Publications (since 2009):  

A controlled trial of renal denervation for resistant hypertension. Bhatt DL, Kandzari DE, O'Neill WW, D'Agostino R, Flack JM, Katzen BT, Leon MB, Liu M, Mauri L, Negoita M, Cohen SA, Oparil S, Rocha-Singh K, Townsend RR, Bakris GL; SYMPLICITY HTN-3 Investigators. N Engl J Med. 2014 Apr 10;370(15):1393-401. doi: 10.1056/NEJMoa1402670. Epub 2014 Mar 29. PMID: 24678939 [PubMed - indexed for MEDLINE]

Are the culprit lesions severely stenotic?Niccoli G, Stefanini GG, Capodanno D, Crea F, Ambrose JA, Berg R.  JACC Cardiovasc Imaging. 2013 Oct;6(10):1108-14. doi: 10.1016/j.jcmg.2013.05.004. No abstract available. PMID: 24135324 [PubMed - indexed for MEDLINE]


Mechanisms of coronary thrombosis in cigarette smoke exposure. Barua RS, Ambrose JA. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1460-7. doi: 10.1161/ATVBAHA.112.300154. Epub 2013 May 16. Review. PMID: 23685556 [PubMed - indexed for MEDLINE]

Frequency of Takotsubo cardiomyopathy in postmenopausal women presenting with an acute coronary syndrome. Sy F, Basraon J, Zheng H, Singh M, Richina J, Ambrose JA.  Am J Cardiol. 2013 Aug 15;112(4):479-82. doi: 10.1016/j.amjcard.2013.04.010. Epub 2013 May 16. PMID: 23683950 [PubMed - indexed for MEDLINE]

Managing coronary thrombus in the cath lab during PCI. Ambrose JA. Curr Cardiol Rev. 2012 Aug;8(3):200-1

Pathophysiology of coronary thrombus formation and adverse consequences of thrombus during PCI. Srikanth S, Ambrose JA. Curr Cardiol Rev. 2012 Aug;8(3):168-76. Review. PMID: 22920487 [PubMed - indexed for MEDLINE] Free PMC Article

Angiographic correlates in type 1 and 2 MI by the universal definition. Ambrose JA, Loures-Vale A, Javed U, Buhari CF, Aftab W. JACC Cardiovasc Imaging. 2012 Apr;5(4):463-4. doi: 10.1016/j.jcmg.2011.12.016. No abstract available.  PMID: 22498337 [PubMed - indexed for MEDLINE] Free Article

Computed tomographic angiography for localizing the site of plaque  disruption/thrombus: is detection so complex? Ambrose JA, Srikanth S. Circ Cardiovasc Imaging. 2011 Mar;4(2):82-3. doi: 10.1161/CIRCIMAGING.111.963520.


Does angiographic response to wiring of totally occluded vessels predict outcomes in ST-segment elevation myocardial infarction? Ambrose JA, Buhari CF. JACC Cardiovasc Interv. 2011 Jan;4(1):63-5. doi: 10.1016/j.jcin.2010.09.019. No abstract available. PMID: 21251630 [PubMed - indexed for MEDLINE] Free Article

Evaluation of plaque composition by intravascular ultrasound "virtual histology": the impact of dense calcium on the measurement of necrotic tissue. Sales FJ, Falcão BA, Falcão JL, Ribeiro EE, Perin MA, Horta PE, Spadaro AG, Ambrose JA, Martinez EE, Furuie SS, Lemos PA. EuroIntervention. 2010 Aug;6(3):394-9. doi: 10.4244/EIJV6I3A65. PMID: 20884420 [PubMed - indexed for MEDLINE]

Acute myocardial infarction and the five-chambered heart. Lardizabal JA, Javed U, Ambrose JA.         Catheter Cardiovasc Interv. 2011 Feb 1;77(2):228-31. doi: 10.1002/ccd.22793. PMID: 20853361 [PubMed - indexed for MEDLINE]

Acute cigarette smoke exposure reduces clot lysis--association between altered fibrin architecture and the response to t-PA. Barua RS, Sy F, Srikanth S, Huang G, Javed U, Buhari C, Margosan D, Aftab W, Ambrose JA. Thromb Res. 2010 Nov;126(5):426-30. doi: 10.1016/j.thromres.2010.07.021. Epub 2010 Sep 1. PMID: 20813396 [PubMed - indexed for MEDLINE]

The balance between anti-ischemic efficacy and bleeding risk of antithrombotic therapy in percutaneous coronary intervention: a Yin-Yang paradigm. Lardizabal JA, Joshi BK, Ambrose JA. J Invasive Cardiol. 2010 Jun;22(6):284-92. Review. PMID: 20516510 [PubMed - indexed for MEDLINE]

Free Article

Vulnerable plaques and patients: improving prediction of future coronary events.
Ambrose JA, Srikanth S.       Am J Med. 2010 Jan;123(1):10-6. doi: 10.1016/j.amjmed.2009.07.019. Review. PMID: 20102983 [PubMed - indexed for MEDLINE]

Effects of cigarette smoke exposure on clot dynamics and fibrin structure: an ex vivo investigation. Barua RS, Sy F, Srikanth S, Huang G, Javed U, Buhari C, Margosan D, Ambrose JA. Arterioscler Thromb Vasc Biol. 2010 Jan;30(1):75-9. doi: 10.1161/ATVBAHA.109.195024. Epub 2009 Oct 8. PMID: 19815816 [PubMed - indexed for MEDLINE] Free Article

Frequency of elevated troponin I and diagnosis of acute myocardial infarction.
Javed U, Aftab W, Ambrose JA, Wessel RJ, Mouanoutoua M, Huang G, Barua RS, Weilert M, Sy F, Thatai D. Am J Cardiol. 2009 Jul 1;104(1):9-13. doi: 10.1016/j.amjcard.2009.03.003. Epub 2009 May 4. PMID: 19576313 [PubMed - indexed for MEDLINE]

Preventing future acute coronary events: is the target the so-called vulnerable plaque or the high-risk or vulnerable patient? Ambrose JA, Srikanth S. Curr Opin Cardiol. 2009 Sep;24(5):483-9. doi: 10.1097/HCO.0b013e32832ec379. Review.PMID: 19550309 [PubMed - indexed for MEDLINE]