Internal Medicine/Pulmonary & Critical Care

 

Daya Upadhyay, MD

Associate Professor of Clinical Medicine


  Medical School: Topiwala National (T.N.) Medical College, University of Bombay, India      
  Residency:

Internal Medicine & Chest Medicine- Topiwala National (T.N.) Medical College, University of Bombay, India
Internal Medicine - New York University School of Medicine, New York, New York

  Fellowships:

Medicine/Oncology Research - New York University School of Medicine, New York, New York
Pulmonary and Critical Care Medicine - Northwestern University Feinberg School of Medicine, Chicago, Illinois                 

  Board Certified:

American Board of Internal Medicine, Pulmonary Medicine
American Board of Internal Medicine, Critical Care Medicine
American Board of Internal Medicine


  Awards and Recognition:

Developmental Cancer Research Award, Stanford Cancer Institute, 2011
Breathe California Award, Breathe California of Bay Area Foundation, 2011
Clinical Research Award in Women's Lung Health (Fellow: Ariel), CHEST Foundation, 2011
Developmental Cancer Research Award - Stanford Cancer Institute, 2012
Breath California Award - Breathe California of Bay Area Foundation, 2012
BioGENEius Challenge Award (Trainee: Pareek) 
Advancement in the Future of Healthcare Award (Trainee: K Pareek) - John Muir Health, 2012
Science and Engineering award (Trainee: Pareek), Contra Costa County Science and Engineering Fair Placement Award, 2012
Developmental Cancer Research Award, Stanford Cancer Institute, 2013
Breath California Award - Breathe California of Bay Area Foundation, 2013
Research Award - B J. Addario (BJA) Foundation and Levy Foundation, 2013
CCFMFG Research Award 2014
Surgeon General Award from the Department of Public Health (Trainee: Theresa Santiago) 2015
CALIFORNIA STATE SCIENCE FAIR Nominee for Research Award (Trainee: Theresa Santiago) 2015
American Thoracic Society 2016 MTSA Award (Trainee Fellow: Dr. V. Ifeacheo)
Resident Research Award UCSF Fresno 2016 – 2nd Place Trainee -Dr. James
Resident Research Award UCSF Fresno 2016 – Winner Trainee - Dr. Risco

  Publications:

Zhang J, Kamdar O, Le W, Rosen GD, Upadhyay D.  Nicotine induces resistance to chemotherapy by modulating mitochondrial signaling in lung cancer.  Am J Respir Cell Mol Biol, 40(2):135-146, 2009.


Ayala E, Kagawa F, Wehner J, Tam J, Upadhyay D.  Rhabdomyolysis Associated with 2009 Influenza A (H1N1).  JAMA; 302 (17):1863-4; 2009.


Kamdar O, Le W, Ahuja R, Rosen E, Rosen GD, Upadhyay D.  GSK-3[beta] Mediates Nicotine-Induced Proliferation in Endothelial Cells.  Am J Respir Cell Mol Biol, 180:A356, 2009.


Shen T, Le W, Yee A, Kamdar O, Hwang PH, Upadhyay D.  Nicotine induces inhibition of apoptotic pathways in airway epithelial cancers.  Am J Rhinol, 24(2):e73-77, Mar 2010.


Chang W, Wei K, Jacobs SS, Upadhyay D, Weill D, Rosen GD.  SPARC suppresses apoptosis of IPF fibroblasts through constitutive activation of {beta}-catenin.  J Biol Chem. 12; 285 (11):8196-206; Mar 2010.


Le W, Wang W, Ghani M, Upadhyay D.  Circulating Blood MicroRNAs in the Diagnosis of Lung Cancer, Am J Respir Crit Care Med, 181: A3482, 2010.


Venkatramana A, Le W, Wang W, Upadhyay D.  Sensitization of CD44 Cancer Stem Cell Apoptosis by Sequential Inhibition of S-Phase.  Intel National Science Competition Award Winning Paper, (no page numbers) March 2010.


Wang W, Le W, Ahuja R, Cho DY, Hwang PH, Upadhyay D.  Inhibition of inflammatory mediators: role of statins in airway inflammation.  Otolaryngol Head Neck Surg.  Jun;144(6):982-7, 2011.


Wang W, Le W, Cho D-Y, Hwang PH, Upadhyay D.  Novel Effects of Statins in Enhancing Efficacy of Chemotherapy in Nasopharyngeal Carcinoma Cells.  Int Forum Allergy Rhinol.  Jul;1(4):284-9, 2011.


Ghani M, Le W, Wang W, Gutsche M, Upadhyay D.  Let-7a Mediated Regulation of Oct4 and Sox2 in Lung Cancer.  Am J Respir Crit Care Med, 201, 5073: 356, 2011.


Cho D-Y, Wang W, Le W, Hwang PH, Upadhyay D.  Dysregulated microRNAs in chronic airway inflammation.  Allergy & Rhinology 2012. in review


Ariel D, Upadhyay D.  The role and regulation of microRNAs in asthma.  Curr Opin Allergy Clin Immunol.  Feb; 12 (1):49-52, 2012.


Pinkerton KE, Rom WN, Akpinar-Elci M, Balmes JR, Bayram H, Brandli O, Hollingsworth JW, Kinney PL, Margolis HG, Martin WJ, Sasser EN, Upadhyay D, Smith KR, Takaro TK; American Thoracic Society Environmental Health Policy Committee.  An official American Thoracic Society workshop report: Climate change and human health.  Proc Am Thorac Soc. Mar 9(1):3-2012.


Swamy S, Le W, Ghani M, Wang W, and Upadhyay D.  Oct4 targeted apoptosis of CD133+ Tumor Initiating Cells in Non-Small Cell Lung Cancer.  Am J Respir Crit Care Med, 201, 5073:356, 2013.

Ghio AJ, Soukup J, Dailey LA, Tong H, Cheng W, Samet JM, Kesic M, Upadhyay D, Budinger G, Mutlu GM.  Sequestration of mitochondrial iron by silica particle initiates a biological effect.  Am J Physiol Lung 2013.


Upadhyay D. Enforcing New Laws: FDA to Regulate Nicotine and Tobacco Products. Editorial Article for Occupational and Environmental Health Network ACCP; CHEST Physicians, 4(8):20, Aug 2009.

 

P Doddamreddy, D Vijay, E Tang, D Upadhyay.  Enhanced Expression of Program Death Ligand-1 (PD-1) indicates significant inhibition of tumor associated T-cell immunity.  AM J Respir Crit Care Med 191:2015: 2415.

 

A Rashidian, M Sachdeva, PK Mills, MW Peterson, D. Upadhyay.  Lung Cancer Rates are Diffenentially influenced by ethinicity and geography in Central California.  Am J Respir Crit Care Med 191:2015: A 3591.
               
M. Sachdeva, E Tang, D Vijay, PK Mills, MW Peterson, D Upadhyay.  Epidermal Growth Factor Receptor Mutations in Hispanics with NSCLC.  Am J Respir Crit Care Med 191:2015: 5080.
               
W. Le, W. Wong, M Ghani, K Pareek, D Upadhyay.  Enhancing Apoptosis of Resistant Tumor Cells by Resveratrol using sequential sensitization.  Am J Respir Crit Care Med. 191:2015; 2417.
               
W Le, W Wong, M Ghani, R Ahuja, D Upadhyay.  Detection of microRNAs association with tumor dissemination and Durg resistance in Exhaled breath in lung cancer.  Am J Respir Crit Care Med.  191:2015: 3482.

Upadhyay D. Growth of Lung Nodule Program.  Fresno Bee 2015

Upadhyay D.  American Lung Association: Doctors for Climate Health - California's Clean Air Act. 2015

 

V. Ifeacho, G. Rubiaco, M. Risco, A. Ryazantsev, K. Almodovar, O. James, D. Upadhyay. Elevated plasma Ciz1b variant expressions in Non-small Cell Lung Cancer are reduced after surgical resection of stage I lung cancer.  Am J Respir Crit Care Med 193:2016:A2579

 

K. Almodovar, V. Ifeacho, M. Sachadeva, A. Ryazantsev, G. Rubiaco, M. Risco, D. Upadhyay. Role of plasma ELMO3 in the diagnosis of Non-small cell Lung Cancer.  Am J Respir Crit Care Med 193:2016:A2574

 

Ryazantsev, V. Ifeacho, G. Rubiaco, M. Risco, O. James, K. Almodovar, D. Upadhyay. Circulating Stanniocalcin-1 in the diagnosis of Lung Cancer. Am J Respir Crit Care Med 193:2016:A6659

 

V. Ifeacho, O. James, M. Risco, G. Rubiaco, A. Ryazantsev, K. Almodovar, D. Upadhyay. Differentiating Coccidioidomycosis from Lung Cancer in High Risk Individuals Am J Respir Crit Care Med 193:2016:A1289

 

V. Ifeacho, M. Risco, A. Ryazantsev, O. James, G. Rubiaco, K. Almodovar, D. Upadhyay. Ciz1b variant As a Surrogate Marker in Surveillance of Lung Cancer Recurrence.  Am J Respir Crit Care Med 193:2016:A3129

  Research Goals:

Translational Research in Medicine


1) Development of Research Bio-Repository at UCSF-Fresno.
2) Develop Interdepartmental Translational Research Project
3) Train Fellows, Residents and Students in conducting Translational Research.
4) Conduct Translational Research in Lung Nodule to detect molecular markers for early diagnosis and monitoring of lung cancer.
5) Quality Improvement Project in Lung Nodule and Lung Cancer: i) Duration of Referral to Diagnosis of Lung cancer, Diagnosis of initiation of treatment and/ surgery for lung cancer, ii) Quality of Life in Lung Cancer patients iii) Mortality Statistics iv) Standardization of Molecular Marker testing in patients with cancer.  v) Initiate mutation based SOG and NCCN Network clinical trials.

6) Detect diagnostic molecular markers for endemic cocci in patient presenting with lung nodule.