Internal Medicine/Neurology


Jeffrey Rosenfeld, MD, PhD

Professor of Clinical Neurology
Professor, Clinical Neurology, UCSF
Director, Neuromuscular Program









  Medical School: University of Maryland
  Residency: Hospital of the University of Pennsylvania
  Graduate School: : University of Connecticut
  Doctorate: University of Connecticut
  Post-Doctoral Research Fellowship: Neuropathology / Neurology, Johns Hopkins School of Medicine
  Board Certified: Neurology
  Awards and Recognition:
  • American Neurologic Association ( ANA, elected membership)
  • American Academy of Neurology – Fellow (FAAN)
  • American Homecare and Hospice Physician of the Year 2006
  • Chairman, ALS Association Clinical Grant Committee.
  • MDA Annual Spirit Award 2007
  • America’s Best Doctors  2004-2008
  • Muscular Dystrophy Association Outstanding Clinic Award
  • Zeritsky Research Award, Department of Neurology, University of Pennsylvania
  • Maryland State Senatorial Scholarship
  • Combined Accelerated Program in Psychiatry (CAPP)
  • University of Maryland School of Medicine Competition, 1st, 2nd, 4th prize.
  • University of Maryland School of Medicine
  • Honors in Neurology
  • Honors in Pathology Research
  • Honors in Neuroscience
  • International Motor Neuron Disease Association – program committee


  Publications: (last 5 years)  
  1. Rosenfeld, J.  Drug Cocktails. Amyotrophic Lateral Sclerosis & Other Motor Neuron Disorders Suppl 1 1-3.  2004.
  2. Rosenfeld, J   Multi-drug ‘Cocktail’ Therapy in Amyotrophic Lateral Sclerosis:  The Case For a Multi-drug Approach  Muscle Nerve 2004.
  3. Cameron, A., Rosenfeld, J.  The Role of Creatine in the Management of Amyotrophic Lateral Sclerosis and Other Neurodegenerative Disorders   CNS Drugs 18(13) 1-14 2004.
  4. Hemendinger, R.,  Wang J. , Malik, S. Persinski, R., Copeland, J., Emerich, D.,  Gores, P., Halberstadt C. and Rosenfeld, J.. Sertoli cells improve survival of motor neurons in SOD1 transgenic mice, a model of amyotrophic lateral sclerosis. Exp. Neurology, 196:235-243  2005.
  5. Rosenfeld, J., Swash, M.  What’s in a name?  Lumping or splitting ALS, PLS, PMA and the other motor neuron diseases.  Neurology 66 1-2 2006.
  6. Alter J. Lou F. Rabinowitz A. Yin H. Rosenfeld J. Wilton SD. Partridge TA. Lu QL. Systemic delivery of morpholino oligonucleotide restores dystrophin expression bodywide and improves dystrophic pathology. [Journal Article] Nature Medicine. 12(2):175-7, 2006 Feb.
  7. Dunckley, T., Craig, D.W., Huentelman, M.J., Pearson J., Szelinger, S.  Joshipura, K., Halperin, R., Stamper, C.,  Letizia, D., Hesterlee, S.E., Pestronk, A., Levine, T., Bertorini, T., Graves, M.C., Mozaffar, T., Jackson, C.E., Bosch, P., Barohn, R., Lomen-Hoerth C., Rosenfeld, J., O’Connor, T., Zhang, K., Crook, R., Hutton, M., Ryberg H., Mitsumoto, H., Bowser, R., Miller, R.G., Appel, S.H.,  Stephan, D.A., . Whole-genome analysis of sporadic amyotrophic lateral sclerosis. New England Journal Medicine 357(8) 775-88 2007.
  8. Keramaris-Vrantsis, E.,Lu, P.J., Doran, T., Zillmer, A., Ashar, J.,  Esapa, C.T., Benson M.A., Blake, D.J., Rosenfeld, J., Lu, Q.L.  Fukutin-related protein localizes to the Golgi apparatus and mutations lead to mis-localization in muscle in vivo.  Muscle Nerve.  36(4) 455-65 2007.
  9. Panov, A.V., Dikalov, S., Shalbuyeva, N., Hemendinger, R., Greenamyre, J.T., Rosenfeld, J. Species and Tissue Specific Relationships Between Mitochondrial Permeability Transition and Generation of ROS in brain and Liver Mitochondria of Rats and mice.  American Journal of Physiology: Cell Physiology 292 C708-C718 2007.
  10. Hemendinger RA. Armstrong EJ 3rd. Persinski R. Todd J. Mougeot JL. Volvovitz F. Rosenfeld J.  Huperzine A provides neuroprotection against several cell death inducers using in vitro model systems of motor neuron cell death. Neurotoxicity Research. 13(1):49-61, 2008 Jan.
  11. Rosenfeld J. Ellis A. Nutrition and dietary supplements in motor neuron disease. Physical Medicine & Rehabilitation Clinics of North America. 19(3):573-89, x, 2008 Aug.
  12. Rosenfeld, J., King, R.M., Jackson, C.E.,Bedlack, R.S., Barohn R., Dick, A., Phillips, L., Chapin, J., Gelinas, D., Lou, J-S  Creatine monohydrate in Amyotrophic Lateral Sclerosis: Effects on strength, fatigue, respiratory status and ALSFRS.   Amyotrophic Lateral Sclerosis 9(5) 266-272 2008.
  13. Jackson, CE, Rosenfeld, J., Gronseth, G., Barohn, RJ, Dubinsky, R., Simpson, CB, McVey, A., King, RM, Hurbelin, L., and the Muscle Study Group.  A Randomized, Double-Blind Study of Botulinum Toxon type B for Sialorrhea in Patients with ALS. Muscle Nerve 39 (2) 137-143 2009.
  14. Strong, M. J., Grace, G. M., Freedman, M., Lomen-Hoerth, C., Woolley, S., Goldstein, L. H.,Murphy, J., Shoesmith, C., Rosenfeld, J., Nigel Leigh, P., Bruijn, L., Ince, P., Figlewicz,,D.  Consensus criteria for  the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis  FIRST publication Jan 2009



  1. Jackson, C. Rosenfeld J. Symptomatic pharmacotherapy: Bulbar and Constitutional symptoms.  In Amyotrophic Lateral Sclerosis In: Mitsumoto, Przedborski, Gordon, Del Bene (eds).  Taylor and Francis Baltimore Maryland 2005.
  2. Rosenfeld, J.,  Ellis, A Nutrition and Dietary Supplements in Motor Neuron Disease. In Physical Medicine and Rehabilitation Clinics of North America. Carter, G., Weiss, M. eds.  Elsevier, Amsterdam, The Netherlands.  Vol 19 (3) 573-590 2008



  1. Wright, A., Rosenfeld, J.  VitalStim™ for the Treatment of Dysphagia in Patients with Motor Neuron Disease.  International Motor Neuron Disease Association, Philadelphia, PA.  ALS and other Motor Neuron Disorders 5(supp2) p.31  2004.
  2. Cannon, A., Rosenfeld, J.  The impact of multidisciplinary care and adaptive equipment on ALSFRS-R decline.  International Motor Neuron Disease Association, Philadelphia, PA.  ALS and other Motor Neuron Disorders 5(supp2) p. 41  2004.
  3. Young, A., Rosenfeld, J.  The 2003 ALS Caregiver Conference: A 6-Month Retrospective Impact Study.  International Motor Neuron Disease Association, Philadelphia, PA.  ALS and other Motor Neuron Disorders 5(supp2) p. 11  2004.
  4. King RM, Rosenfeld, J.  Abnormal Sleep Study as an Early Indication for Noninvasive Positive Pressure Ventilation in Patients with ALS.  International Motor Neuron Disease Association, Philadelphia, PA.  ALS and other Motor Neuron Disorders 5(supp2) p. 124  2004.
  5. Ellis, A., Rosenfeld, J.  Challenging the Nutritional Standards of Care for Patients with Amyotrophic Lateral Sclerosis.  International Motor Neuron Disease Association, Philadelphia, PA.  ALS and other Motor Neuron Disorders 5(supp2) p. 127  2004.
  6. Rosenfeld, J., Hemindinger, R., Malik, S., Persinski, R., Wang, J.  Sertoli Cells: A Novel Source of Neuroprotective Cells.  International Motor Neuron Disease Association, Philadelphia, PA.  Published Proceedings 2004.
  7. Hemendinger, R., Volvovitz, F., Rosenfeld, J.  Rescue from staurosporine – induced cell death by the antioxidant, huperzine A: an in vitro drug screening model for ALS.  Society for Neuroscience 35th Annual Meeting, Washington, D.C.  Published Proceedings 2005.
  8. King, RM, Rosenfeld, J., Multi-Drug Cocktail Therapy in ALS:  A feasibility and Safety Study.  Amyotrophic Lateral Sclerosis, 6(4)  Suppl.1 p. 119  2005.
  9. Rosenfeld, J., King, RM, et al. Multi-Center Trial of Creatine Monohydrate in Patients with ALS. Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases 6(4) Suppl.1 p.13  2005.
  10. Pacicco, TJ, Lindblom, SS, Pope TA, Rosenfeld, J. Enhancing PEG Tube Placement: A new device for maintaining respiratory function during endoscopy in ALS patients.   Amyotrophic Lateral Sclerosis, 6(4), Suppl. 1 p. 25 2005.
  11. Panov, AV, Persinski, R., Mougeot J-L,Hemendinger, R., Rosenfeld J. Structural and Functional Differences Between Brain and Spinal Cord Mitochondria: Implications for understanding Amyotrophic Lateral Sclerosis.  Society for Neuroscience Annual Meeting
  12. Rosenfeld, J,  King R, Blythe A  Intrathecal Baclofen Pump for Treatment of Medically Refractory Rigity and Spasticity in Patients with Motor Neuron Disease.  Amyotrophic Lateral Sclerosis 7(3) Suppl.1  45 – 47  2006.
  13. Rosenfeld, J., King, RM, Blythe, A., Lindblom, S. Skipper, E. Phrenic Nerve Pacing to Improve Function in Patients with Amyotrophic Lateral Sclerosis.  Amyotrophic Lateral Sclerosis, 7(3), Suppl. 1, p. 66 2006.
  14. Rosenfeld, J.  Aggressive approaches to patient management in patients with motor neuron disease. Amyotrophic lateral Sclerosis (suppl 1) 9 p. 21 2009